PANNORAMIC Confocal - Digital Slide Scanner

Overview

PANNORAMIC Confocal offers confocal scanning for research pathology applications in unprecedented image quality and at unparalleled speed.

Research laboratories require maximum image quality (with low bleaching and phototoxicity) at a considerable scanning speed. While competitive technologies have not been able to deliver this, PANNORAMIC Confocal from 3DHISTECH offers fast and high-quality confocal scanning for molecular pathology applications by combining confocal imaging with award-winning whole-slide scanning technology.

Thanks to its innovative imaging technology, PANNORAMIC Confocal offers brightfield and fluorescence confocal scanning in unprecedented quality and speed for molecular pathology applications at low running costs, contributing to increased productivity for research laboratories.

The benefits of using PANNORAMIC Digital Slide Scanners

• Scan with the same device histology, cytology or molecular stained tissues with brightfield or fluorescence mode!
• High image quality even in case of thick samples: Thick, standard and thin sample compatible (3-6 µm)
• Scan daily routine and archive slides: Compatible with thick, standard and thin glass slides (0.8-1.2 mm)
• Saves scan time and storage space: Automatic tissue detection - no empty area scanning
• Suitable for suboptimal (fat, smear, blood etc.) samples: Flexible settings for various tissue properties
• Wide range of resolutions: Automatic 20x and 40x objective changer
• Compatibility with various coverslippers: Use film or glass coverslip
• LIS, HIS and immunostainer integration: Dual barcode compatible
• Flexible slide access: Direct scanning on slide server
• Quick zoom of images, true colour representation: Purpose built MRXS file format for lossless compression, supporting BF, FL, multilayer scanning
• Built-in quality control: Quantitative focus quality measurement

Key Features

Innovative imaging technology

PANNORAMIC Confocal uses innovative structured illumination confocal imaging to overcome the limitations of spinning pinhole-disc techniques. This delivers the highest light efficiency with minimal bleaching and fastest scanning speed. Colocalized imaging is available with both fluorescent and brightfield illumination. Also, SW DDIC (Digital Differential Interference Contrast) is used to ensure low-contrast brightfield visualization.

Unique speed-up technologies

Technologies to increase scanning speed include darkfield and fluorescent preview, a Lumencor LED light engine for highest possible illumination, a scientific SCMOS camera combining high sensitivity and low noise to ensure short exposure times as well as an automated water immersion system for high NA objective. These solutions ensure a scanning speed up to 20 times faster than scanners using the spinning disc technology.

Anti-bleaching solutions

The structured illumination technology ensures minimum bleaching by collecting every usable light from the sample. Unnecessary sample illumination is guaranteed by hardware light triggering and reducible light intensity preserves the sensitive samples. The high-brightness confocal mode makes possible to detect weak signals without increasing the excitation light intensity.

Low operating costs

Compared to competitive technologies (laser scanning confocal and spinning disc), PANNORAMIC Confocal offers an unbeatable advantage in running costs: while competitive texhnologies use expensive lasers with low lifetime (1-2,000 hours), Confocal’s LED light engine has a lifetime of over 15,000 hours.

Advanced image handling

Last but not least, Confocal offers multiple image export options (ROI, grayscale/color, multichannel) as well as lossless export to third-party 3D applications.        

Scanner Software for Research

PANNORAMIC Scanners are powered by the PANNORAMIC Scanner Software for Research, which provides versatile, fast and high-quality slide scanning according to the imaging needs of cancer research laboratories, pharmaceutical companies or medical research institutes. Its key features include

• New Graphical User Interface (GUI)
• Scanning profiles for individual slides, multiple scanning locations and separate scanning of TMA slides for flexibility
• Several focus modes, new intensity stitching algorithm, two multilayer scanning options and further improved deconvolution for superior image quality
• Highly adjustable software and hardware settings
• Customizable user interface and scanning workflow
• Built-in slide conversion into the following file formats: DICOM, Tiled TIFF

Complementary Software Solutions

The 3DHISTECH software product portfolio is the most comprehensive one on the market. Whether it is tissue microarrays, IHC stainings, quantitative measurements, e-learning application and more, 3DHISTECH offers solutions for your research work.

Important Notice

Please note that the PANNORAMIC Confocal digital slide scanner is for research use only, and cannot be used for patient diagnosis or treatment selection.

Specifications