BIO CELLX Biodispenser

Introducing Biodispensing

As industry leaders in bioprinting, and thanks to our valuable customers, our knowledge of 3D biology research remains unrivaled. This in-depth understanding of 3D biology and our customers’ needs has enabled the development of biodispensing. Through a lens of bio convergence, we have harmonized the best practices within bioprinting with the higher throughput, automation-capable technology present within the liquid handling field. Now we’re introducing the world’s first ever biodispenser – and a new modality to the world of biofabrication. A hassle- and engineering-free method to develop reproducible 3D models which are compatible with existing analysis workflows.

Welcome to the era of biodispensing.

Effortless hydrogel extrusion

Each of the three material mixing stations in the BIO CELLX offer precise temperature control, ranging from 0°C to 60°C, allowing for hassle-free printing of ECM Hydrogels

High throughput like never before

Rapidly plate up to 384-well plates with controlled dispensing

Unprecedented reproducibility

Using positive displacement technology, and features like onboard cell mixing, the BIO CELLX provides unprecedented reproducibility across wells and constructs

Workflow

The BIO CELLX enables our customers a cost-effective and time-efficient workflow, with high reproducibility at a high throughput. The easy-to-use biodispensing system allows you the time and energy to focus on your research.

Features

Precise & reproducible

The BIO CELLX is a high-precision positive displacement extrusion system. This technology provides reproducible results every single time – regardless of the dispensed material.

Uncompromised sterility

CELLINK’s fully enclosed, proprietary Clean Chamber technology, combined with a patent pending de-lidding solution, ensures the sterility of the entire workflow when working on a benchtop in a laboratory environment.

Flexible, validated geometries

Developed by scientists for scientists, pre-validated protocols ensure consistent and reproducible 3D model generation, guiding users through every step of the workflow, from material selection to dispensing to downstream analysis methods.

Automated Calibration

To achieve an industry-leading positional accuracy, a sensor suite measures the position of each of the dispensing orifices in relation to the position of the vessel. An algorithm compensates any inaccuracies to ensure the precise position of the dispensed model.

Nozzle priming, now with AI

For the first time ever, ensure flawless dispensing courtesy of artificial intelligence-powered nozzle priming, with onboard bubble detection for consistent cell-laden constructs.

No modeling required

Thanks to the variety of 3D models built into BIO CELLX Studio there’s no longer a need to spend time modeling in CAD software.

FEATURE HIGHLIGHT: Proprietary Material Mixing Station

Effortless biomaterial preparation. Every time.

With a novel patent pending dispensing mechanism onboard, the BIO CELLX brings a new degree of ease to creating physiologically relevant 3D models, with the ideal matrix environment, and biomechanical cues for your downstream assays.

Maximize workflow efficiency

Thanks to the automatic mixing of bioinks, reagents and cell suspension, the BIO CELLX significantly reduces the preparation time in your 3D cell culture process.

Unparalleled repeatability

Automated bioink preparation reduces the variation in mechanical properties, cell viability, pH and air content of samples, enabling consistent results every single time.

Homogenous cell density

With gentle mixing built into the BIO CELLX, cell density remains evenly distributed throughout the dispensing process, ensuring reproducible 3D models across wells.

3D geometries to accelerate your discoveries

SOFTWARE

BIO CELLX Studio

Maximize walk-away capabilities through the power of automation. A brand-new intuitive version of DNA Studio guides users through the entire biodispensing process, from setting up the system to selecting one of the pre-set and pre-validated protocols.

No training required.

Key features:

• No-code solution
• No modeling required
• Touchscreen optimized
• Flexible well selection
• Connect multiple instruments
• Adjustable droplet size
• Camera view

ENHANCED FLEXIBILITY WHEN REQUIRED

Discovery mode

We understand research needs to be developed over time and, while our protocols are continuously validated by our scientists, Discovery Mode allows you the ability to develop your own custom protocols.

Optimize dispensing parameters to work with hydrogels you know.

CUSTOM BIOINK SUPPORT

Optimize the dispensing parameters to work with hydrogels that you already know.

OPTIMIZE MIXING PARAMETERS

Adjust mixing parameters to achieve higher cell viability or better homogeneity of the solution.

STL-FILE SUPPORT

3D bioprint from STL-files for full freedom of design.

FLEXIBLE MATERIAL CHOICE

Dispense up to 3 biomaterials and assign them per well or construct