Neural Circuit Research

Overview

The fiber photometry system records changes in the fluorescence intensity of neurons in a specific brain area to reflect neuronal population activity. In the study of neural circuits, the fiber photometry system can perform long-term stable monitoring of the neurons of freely moving animals, and explore the correlation between neural activity and animal behavior.

Fiber Photometry System Applications:

Highlights of R821 Fiber Photometry System

• Three kinds of excitation light sources, that are 410nm、470nm and 560nm, are respectively used for excitation of reference, green fluorescence and red fluorescence;

• Support up to 9 channels, suitable for simultaneous experiment of multiple animals or multiple brain locations;

• Dual highly sensitive detectors enabling independent and sequential detection to avoid interference of fluorescence excitation and detection, acquiring more accurate signals;

• Professional acquisition and analysis softwares are flexible and easy to operate with data processing functions available. No matlab programming is required;

• Supports multiple acquisition modes including continuous acquisition, interval acquisition, acquisition upon trigger, delayed acquisition and timing acquisition;

• Live display of DeltaF/F acquisition to check scale of signal changes during acquisition;

• Customized adjustment of output signal parameters, easily trigger and control external excitation equipment to achieve closed-cycle control of excitation and recording;

• Compatible with optogenetics for recording and stimulation at the same site.

Stable Data Acquisition

Fluorescence Comparison

Advantages

One-click Graphs
Including fluorescence heatmaps, curve graphs, animal trajectory graphs, etc

Signal Acquisition Sensitivity
Meets the need for weak signal detection at the picowatt level (axons/glia)

Professional Data Analysis
Comprehensive data analysis, with a complete pre-processing process, and event refinement analysis, support for multi-dimensional results and format output

High Integration
The whole machine and software integrated design, built-in optogenetic interface, to achieve the same site stimulation and recording

Stable Performance
Over 500 hours of stable acquisition to meet the needs of sleep and other experiments

Strong Expansion
With 4 input and 4 output digital interface and excitation light combination mode, support for up to 9-channel acquisition